Synthesis of 125I-labeled 14-iodo-9-tetradecynoic acid
نویسندگان
چکیده
منابع مشابه
Radio-iodination of monoclonal antibody using potassium [125I]-(4-isothiocyanatobenzylammonio)-iodo-decahydro-closo-dodecaborate (iodo-DABI).
BACKGROUND Negatively-charged polyhedral boron clusters can be easily halogenated with highly stable boron-halogen bonds and are promising in radionuclide diagnostics and cancer therapy. MATERIALS AND METHODS The radio-iodination conditions for the closo-dodecaborate anion and for the conjugation of its labeled isothiocyanatobenzylammonio derivative to the monoclonal antibody (mAb) were optim...
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The enzyme β-tyrosinase (tyrosine phenol lyase, EC 4.1.99.2) has been shown [8, 9, 15] to catalyze the decomposition of L-Tyr to phenol, pyruvate and ammonia. Under some conditions, this enzyme also participates in the reverse reaction leading to formation [10, 12, 13] of L-Tyr (Scheme 1). As a metabolism of L-Tyr is an important process of the living cells, the mechanism of the above reaction ...
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Sagamicin, an aminoglycoside antibiotic, was labeled with tritium by means of a platinum catalyzed hydrogen exchange reaction and by carbon-14 in two biosynthetic procedures. 14C-Methyl-L-methionine was used as the radioactive precursor in these biological processes involving Micromonospora sagamiensis. The distribution of radioactivity in 14C-sagamicin and gentamicin C1 was studied by mild aci...
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Iodinated forms of C-reactive protein (CRP), soluble modified CRP (mCRP-sol), and suspended mCRP (mCRP-susp) were injected iv into CD-1 mice, for analysis of their pharmacokinetics (PK) and biodistribution (BD). The plasma half-life of 125I-CRP, measured as 4.7 hr, agrees closely with previous reports. The PK and BD characteristics for 125I-mCRP-sol and 125I-mCRP-susp were comparable to each ot...
متن کاملSynthesis of the 123I- and 125I-labeled cholinergic nerve marker (-)-5-iodobenzovesamicol.
The highly toxic curraremimetic and cholinergic neuron marker (-)-5-iodobenzovesamicol (IBVM) has been labeled with iodine-125 and iodine-123. [125I]IBVM, suitable for animal distribution and ex vivo autoradiographic studies, was synthesized by solid-state exchange; isolated yields were 65-89% with specific activities in the range of 130-200 Ci/mmol. The synthesis of no-carrier-added (-)-5-[125...
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ژورنال
عنوان ژورنال: Journal of Labelled Compounds and Radiopharmaceuticals
سال: 1981
ISSN: 0362-4803
DOI: 10.1002/jlcr.2580180911